Gou H-L, Zhang X-B, Bao N, Xu J-J, Xia X-H, Chen H-Y (2011) Label-free electrical discrimination of cells at normal, apoptotic and necrotic status with a microfluidic device. Gilchrist KH, Barker VN, Fletcher LE, DeBusschere BD, Ghanouni P, Giovangrandi L, Kovacs GTA (2001) General purpose, field-portable cell-based biosensor platform. Gawad S, Schild L, Renaud PH (2001) Micromachined impedance spectroscopy flow cytometer for cell analysis and particle sizing. Biotechnol Bioeng 111:1161įratamico PM, Strobaugh TP, Medina MB, Gehring AG (1998) Detection of Escherichia coli 0157:H7 using a surface plasmon resonance biosensor. Sensors Actuators B Chem 224:275Įsfandyarpour R, Javanmard M, Koochak Z, Harris JS, Davis RW (2014) Nanoelectronic impedance detection of target cells.
Layouteditor cell magnification portable#
Lab Chip 12:4499Įmaminejad S, Paik K, Tabard-Cossa V, Javanmard M (2016) Portable cytometry using microscale electronic sensing. Lab Chip 13:3903Įmaminejad S, Javanmard M, Dutton RW, Davis RW (2012) Microfluidic diagnostic tool for the developing world: contactless impedance flow cytometry. Proc Natl Electron Conf 12:1034ĭu E, Ha S, Diez-Silva M, Dao M, Suresh S, Chandrakasan AP (2013) Electric impedance microflow cytometry for characterization of cell disease states. J Clin Microbiol 37:35Ĭoulter WH (1956) High speed automatic blood cell counter and cell size analyzer. KeywordsĬiceron L, Jaureguiberry G, Gay F, Danis M (1999) Development of a Plasmodium PCR for monitoring efficacy of antimalarial treatment. This device is therefore suitable for cost-effective screening and testing of medical and food safety in developing countries. While this tool is low cost, it retains the sensor’s functionality, which can detect the single particle in the sensing region. In addition, with a simple cleaning process, such as ultrasonic cleaning, the microneedles can be reused. It was easy to remove the microneedles from the disposable microchannel of PDMS. This device was also capable of distinguishing the concentration of cells in the suspension fluid. Two microneedles at half the height of the microfluidic device were used as a measuring electrode to determine electrical impedance when cells were present in the sensing field. In this work, an integrated microneedle microfluidic device to detect and discriminate 9 μm and 16 μm microbeads was developed.
The details information of single cells such as cell size, membrane capacitance, and cytoplasm conductivity also can be obtained by impedance measurement over a wide frequency range. Microfluidic impedance cytometry has been utilized to detect and measure the electrical impedance of single biological particles at high speed.
A microfluidic device for detecting a single particle has emerged as a noninvasive technique for diagnostic and prognostic patients with cancer suspected.
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